Open Studies

(Updated July 2021)

ACCRF has compiled a list of clinical trials for ACC patients with progressive disease to consider. This website is updated periodically, but may not list all the pertinent and available trials. Patients may search on their own for recruiting ACC clinical trials on the ClinicalTrials.gov website.

The clinical trials are broken down into three categories.

  • The first table lists studies that are recruiting any and all ACC patients (usually phase II clinical trials).
  • The second table lists studies appropriate for ACC patients whose tumors have been profiled and found to have activating alterations in NOTCH genes (either phase I or II clinical trials).
  • The third table includes clinical trials that incorporate tumor profiling prior to selecting a drug (“basket studies”).

In all cases, patients should consult with their physicians to discuss the appropriate course of action.

Not all clinical trials have similarly strong scientific rationales for why the drugs should be effective in ACC. The most promising studies will involve drugs that (1) target the known mechanisms of action that drive ACC progression, (2) demonstrate activity in preclinical models of ACC, and (3) have reports of clinical benefit in an ACC patient from a case study or Phase I clinical trial. To assist patients in appraising each clinical trial, we indicate whether the evidence supporting the scientific rationale is strong, solid or fair. This assessment is based on the underlying scientific rationale, and does not mean that a particular trial is better or worse for any given patient, and should be considered along with his or her physician.

The table below lists clinical trials that currently are recruiting ACC patients in particular or salivary gland cancer patients. Unless otherwise noted, these studies are for only ACC patients with recurrent or metastatic disease. Links are provided to descriptions of the drugs as well as the www.ClinicalTrials.gov summary of each study.

Clinical Trials for All ACC Patients
Compound TargetsSponsor Locations Scientific Rationale Info Link Contact
Lenvatinib and Pembrolizumab VEGFR and PD-1 Immunotherapy Memorial Sloan-Kettering New York, NY, USA Very Strong View Alan Ho, MD, PhD
646-888-4235
[email protected]
GSK3326595 (for patients without prior systemic drugs) PRMT5 GSK Multiple sites in Canada, France, Netherlands and USA Strong View US: 877-379-3718 [email protected]
EU: +44(0)20 89904466 [email protected]
MYB vaccine and Tislelizumab MYB & PD-1 Immunothera Peter MacCallum Cancer Centre Melbourne, Australia Strong View Jayesh Desai
+61 38559 7810
[email protected]
Lutetium-177-PSMA / Radioligand Therapy PSMA Radboud University Nijmegen, Netherlands Strong View Carla ML van Herpen, MD, PhD
+31243613457
[email protected]
Lutetium-177-PSMA / Radioligand Therapy PSMA Peking Union Medical College Hospital Beijing, China Strong View Zhaohui Zhu, MD
86-13611093752
[email protected]
ATRA Combinations MYB Shanghai Ninth People's Hospital Shanghai, China Strong View Guopei Zhu, MD
021-23271699 ext 5665
[email protected]
APG-115 MDM2 University of Michigan Ann Arbor, MI, USA Solid View Paul L Swiecicki, MD 1-734-647-1017 [email protected]
Ryan Drzewicki [email protected]
Stereotactic Body Radiation Therapy (for patients with up to 3 metastases) Oligometastases Dana Farber Boston, MA, USA Solid View Jonathan D Schoenfeld, MD, MPH
617-632-5296
[email protected]
Glenn J Hanna, MD
617-632-3090
[email protected]
Chidamide and Cisplatin HDAC Fudan University Shanghai, China Solid View Kai Xue, MD
021-64175590
[email protected]
9-ING-41 Plus Carboplatin GSK3beta Actuate Therapeutics Boston, Massachusetts, United States, 02115 Fair View Glenn J Hanna, MD
617-632-3090
[email protected]
Pembrolizumab and Docetaxel PD-1 Immunotherapy University of Chicago Chicago, IL, USA Fair View Alexander Pearson, MD, PhD
[email protected]
Pembrolizumab and Pemetrexed PD-1 Immunotherapy Mayo Clinic Rochester, MN, USA
Scottsdale, AZ, USA
Fair View Clinical Trials Referral Office
855-776-0015
[email protected]
Nivolumab and Ipilimumab and Radiation PD-1 and CTLA-4 Immunotherapy University of Washington Seattle, WA, USA Fair View Susan Masterson
1-206-606-7445
[email protected]
Chidamide HDAC Chinese Academy of Medical Sciences Beijing, China Fair View Mei Dong
+86-10-87788130
[email protected]
EGFR Tyrosine Kinase Inhibitors EGFR Qingdao Central Hospital Qingdao, Shandong, China Fair View Youxin Ji, MD
68665078
[email protected]

Approximately 25% of metastatic ACC patients have tumors with activating alterations in the NOTCH pathway (primarily in the NOTCH1 gene). These tumors behave more aggressively. Patients for whom tumor profiling has identified a NOTCH pathway alteration may wish to discuss the following studies with their physicians:

Clinical Trials for ACC Patients with Activating NOTCH Alterations
Compound TargetsSponsor Locations Scientific Rationale Info Link Contact
CB-103 NOTCH Cellestia Pharmaceuticals Barcelona, Spain
Madrid, Spain
Bellinzona, Switzerland
Saint Gallen, Switzerland
Boston, MA, USA
Houston, TX, USA
Santa Monica, CA, USA
Strong View Florian Vogl, MD, PhD
+41 61 6332957
[email protected]
AL101 (only for patients preceding surgery) NOTCH Ayala Pharmaceuticals Houston, TX, USA Very Strong View Renata Ferrarotto, MD
713-792-6363
[email protected]

Historically, clinical trials involved only one or two treatments. Some newer trials are incorporating tumor profiling to direct patients to many more potential treatments within the same study. These “basket trials” try to match targeted drugs to genomic alterations in each patient’s particular tumor. Some of these trials profile the patient’s tumor as party of the study (NCI-MATCH) while others will suggest treatment decisions based on existing tumor profiling reports (ASCO TAPUR). The clinical trials listed below are not specifically for ACC patients, but may be worth considering in consultation with a knowledgeable physician.

Studies for ACC Patients with Unresectable (Inoperable), Locally-Advanced Tumors
Compound Modality Sponsor Locations Info Link Contact
CV8102 (for superficial and readily-accessible head & neck tumors) Injection of TLR7/8 agonist CureVac Multiple sites in Germany View Thomas Eigentler, Prof. Dr.
[email protected]
Apatinib and Proton Radiation (for inoperable or residual ACC) Shanghai Proton and Heavy Ion Center Shanghai, China View Lin Kong, MD [email protected]
Jiyi Hu, MD [email protected]
Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Radiation Massachusetts General Hospital Boston, MA, USA View Annie W Chan, MD
617-724-1159
[email protected]
Carbon Ion Only Irradiation vs Boost (ACCO) Radiation Heidelberg University Heidelberg, Germany View Klaus Herfarth, Prof. Dr.
+49 6221 568201
[email protected]
Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors (ETOILE) Radiation Hospices Civils de Lyon Multiple sites in France View Pascal Pommier, MD
(0)4 78 78 51 66 ext +33
[email protected]