Published Articles

The table below lists articles in peer-reviewed journals authored by ACCRF-funded investigators.
Date ACCRF PI(s) Title/Subject Journal PubMed
2019 Sep 4 Morris, Chan, Schultz, Ho, Weigelt, Reis-Filho, El-Naggar, Futreal, Agrawal, Ha Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest 31483290
2013 Sep 15 Moskaluk Sinonasal tract and nasopharyngeal adenoid cystic carcinoma: a clinicopathologic and immunophenotypic study of 86 cases. Head Neck Pathol 24037641
2017 Sep 14 Ferrarotto Taking it up a NOTCH: a novel subgroup of ACC is identified. Oncotarget 29137213
2018 Sep 12 Zon, Knoechel, Wick Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med 30209067
2017 Sep 12 Agarwal, Moskaluk, Wick A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug. Sci Rep 28900283
2016 Sep 10 Faquin Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall. Am J Clin Pathol 27614667
2013 Sep 1 Nor Salivary gland cancer stem cells. Oral Oncol 23810400
2011 Sep 1 Moskaluk, Stenman Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 21572406
2013 Aug 8 Yarbrough TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene 23027130
2016 Aug 5 Weigelt, Reis-Filho Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer. Mod Pathol 27491809
2016 Aug 4 Yarbrough, Ivanov Clinical and molecular insights into adenoid cystic carcinoma: Neural crest-like stemness as a target. Laryngoscope Investig Otolaryngol 28894804
2009 Aug 26 Kirsch Perineural invasion detected by high-field 3.0-T magnetic resonance imaging. Am J Otolaryngol 20015797
2012 Aug 15 El-Naggar A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer 22179977
2008 Aug 15 El-Naggar Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res 18698036
2016 Aug 14 Brait, Ha Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget 27312343
2016 Aug 1 Sala Cutaneous cylindroma: it’s all about MYB. Cancer Immunol Res 27185061
2016 Aug 1 Schoenfeld, Dranoff, El-Naggar Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes. Cancer Immunol Res 27312343
2014 Aug 1 Stenman Diagnostic and therapeutic implications of new molecular biomarkers in salivary gland cancers. Oral Oncol 24856188
2013 Aug 1 El-Naggar, Stenman The 3rd Salivary Gland Tumor Workshop meeting report. Head Neck 23677839
2012 Aug 1 Stenman Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. Genes Chromosomes Cancer 22505352
2010 Aug 1 Stenman New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer. Cell Cycle 20647765
2011 Jul 28 El-Naggar Developmental transcription factor EN1-a novel biomarker in human salivary gland adenoid cystic carcinoma Cancer 21800291
2013 Jul 23 Yarbrough, Ivanov Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. Br J Cancer 23799842
2016 Jul 21 Morris, Ho, Chan The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform. JAMA Oncol 27442865
2019 Jul 10 Ramsay First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427). Contemp Clin Trials Commun 31650066
2016 Jul 1 Ha, Wick, Fertig, Brait Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol 27212063
2013 Jul 1 Moskaluk Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming. J Clin Invest 23778135
2013 Jul 1 Futreal,El-Naggar Whole exome sequencing of adenoid cystic carcinoma. J Clin Invest 23778141
2013 Jul 1 Chan The mutational landscape of adenoid cystic carcinoma. Nat Genet 23685749
2011 Jul 1 El-Naggar CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. Cancer 21692051
2011 Jul 1 Ha, Moskaluk Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clin Cancer Res 21551254
2011 Jul 1 Stenman The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. J Pathol 21618541
2015 Jun 5 Stenman Detection of MYB Alterations and Other Immunohistochemical Markers in Primary Cutaneous Adenoid Cystic Carcinoma. Am J Surg Pathol 26076064
2015 Jun 3 El-Naggar Analysis and significance of c-MET expression in adenoid cystic carcinoma of the salivary gland. Cancer Biol Ther 25923130
2015 Jun 26 Nor BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol 26121939
2013 Jun 25 El-Naggar MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. PLos One 23825564
2015 Jun 16 Dillon, Thomas, Moskaluk Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 25487882
2015 Jun 12 Weigelt, Reis-Filho, Chan, Stenman Genomic landscape of adenoid cystic carcinoma of the breast. J Pathol 26095796
2016 Jun 1 Li Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition-related factors. Ann Diagn Pathol 27180058
2015 Jun 1 Klempnauer Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300. Mol Cancer Ther 25740244
2013 Jun 1 El-Naggar Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol. 23583282
2010 Jun 1 Moskaluk, Futreal, El-Naggar C-kit gene mutations in adenoid cystic carcinoma are rare. Mod Pathol 20514080
2015 May 8 Weigelt, Reis-Filho Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing. Histopathology 25951887
2018 May 3 Ferrarotto A Phase 1 dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors. Ann Oncol 29726923
2017 May 26 El-Naggar, Futreal, Mitani Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. J Natl Cancer Inst 29117356
2017 May 22 Stenman, Wick Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling. J Natl Cancer Inst 28954282
2014 May 22 Queimado Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis. 24853424
2016 May 18 Wong The impact of the MYB-NFIB fusion protooncogene in vivo. Oncotarget 27213588
2017 May 1 Ivanov, Yarbrough, Moskaluk MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma. Stem Cell Res 28500913
2016 May 1 Ferrarotto MYB-fusions and other potential actionable targets in adenoid cystic carcinoma. Curr Opin Oncol 26974847
2015 May 1 Ha MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma. Laryngoscope 25963073
2017 Apr 8 Castilho, Nor Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence. Stem Cell Res 28426972
2017 Apr 4 Moskaluk A Phase II study of Dovitinib in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma. Clin Cancer Res 28377480
2019 Apr 22 Morris, Chan, Ho Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nat Med 31011208
2019 Apr 2 Ho Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. J Clin Oncol 30939095
2016 Apr 15 Ivanov, Yarbrough NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res 27084744
2019 Apr 1 Bakst Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer. Int J Radiat Oncol Biol Phys 30562546
2015 Apr 1 Ramsay MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region. PLoS One 25853889
2014 Apr 1 Pusztaszeri, Faquin MYB immunostaining is a useful ancillary test for distinguishing adenoid cystic carcinoma from pleomorphic adenoma in fine-needle aspiration biopsy specimens. Cancer Cytopathol 24302647
2011 Apr 1 Ha Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma. Oral Oncol 21324728
2017 Mar 22 LoRusso, Goncalves A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma. Oncotarget 28415633
2016 Mar 2 Nor, Moskaluk, Wick Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res 26936915
2018 Mar 19 Jimeno, Reyland Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression. Clin Cancer Res 29555661
2019 Mar 1 Moskaluk, Agarwal Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation. EBioMedicine 30765319
2017 Mar 1 Wick A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors. Clin Cancer Res 27733479
2013 Mar 1 Moskaluk Adenoid cystic carcinoma: clinical and molecular features. Head Neck Pathol. 23463073
2013 Mar 1 Stenman Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology 23398044
2012 Mar 1 El-Naggar Developmental transcription factor EN1–a novel biomarker in human salivary gland adenoid cystic carcinoma. Cancer 21800291
2022 Nov 29 Bernstein, Faquin, Lin, Deschler, Aster Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinoma Cell Rep 36450256
2022 Nov 22 Bingle, Ferrarotto Drug-based therapy for advanced adenoid cystic carcinoma: current landscape and challenges based on an overview of registered clinical trials Crit Rev Oncol Hematol 36427771
2022 Nov 20 Kang, Ha Approaches to the Management of Metastatic Adenoid Cystic Carcinoma Cancers 36428790
2022 Oct 18 van Herpen Development and characterization of patient-derived salivary gland cancer organoid cultures Oral Oncol 36265373
2022 Aug 27 van Herpen Identification of Fusion Genes and Targets for Genetically Matched Therapies in a Large Cohort of Salivary Gland Cancer Patients Cancers (Basel) 36077692
2022 Aug 19 Chen A pilot study of 68 Ga-PSMA-617 PET/CT imaging and 177 Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma EJNMMI 35984529
2022 Aug 13 Castilho, Nor Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: different clinical outcomes to the same tumor Crit Rev Oncol Hematol 35973662
2022 Aug 8 Metcalf Clinical disease course and survival outcomes following disease recurrence in adenoid cystic carcinoma with and without NOTCH signaling pathway activation Oral Oncology 35952580
2022 Aug 7 Chen Prognosis of adenoid cystic carcinoma of head and neck and risk factors for lung metastasis Zhonghua 36058663
2022 Aug 5 Ferrarotto, Izumchenko, Agrawal, Aster AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling Cell Death and Disease 35931701
2022 Jul 28 Stenman, El-Naggar, Moskaluk, Ferrarotto, Frierson, Mitani Rearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study Cancers 35954356
2022 Jul 19 Ferrarotto, de Sousa Metastatic Adenoid Cystic Carcinoma: Genomic Landscape and Emerging Treatments Curr Treat Options Oncol 35854180
2022 Jun 20 Bingle MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions Crit Rev Onc Hematol 35738530
2022 Jun 6 Faquin, Deschler Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors Cancer Cytopathol 35666645
2022 Jun 4 Baujat, Atallah Beyond Surgical Treatment in Adenoid Cystic Carcinoma of the Head and Neck: A Literature Review Cancer Manag Res 35693117
2022 Apr 30 Ha, Morris Development and Characterization of MYB-NFIB Fusion Expression in Adenoid Cystic Carcinoma Cancers (Basel) 35565392
2022 Feb 25 Ferrarotto Treatment of Recurrent or Metastatic Adenoid Cystic Carcinoma Curr Oncol Rep 35212920
2022 Feb 23 Metcalf Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer Cancers (Basel) 35267442
2022 Feb 1 van Herpen 68Ga-Prostate-Specific Membrane Antigen-Avid Malignant Pleural Effusion in a Patient With Metastatic Adenoid Cystic Carcinoma and Concordance With 18F-FDG PET/CT Clin Nucl Med 35006109
2022 Jan 19 Dalerba, Moskaluk Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas bioRxiv bioRxiv
2021 Dec 19 Schoenfeld, Hanna, Chau Oligometastatic adenoid cystic carcinoma: Correlating tumor burden and time to treatment with outcomes Head Neck 34927307
2021 Dec 14 van Herpen Excessive toxicity of cabozantinib in a phase II study in patients with recurrent and/or metastatic salivary gland cancer Eur J Cancer 34920917
2021 Nov 1 Klempnauer, Stenman Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner Cancer Lett 34256093
2021 Oct 29 Doggett CT-guided palladium-103 seed brachytherapy for metastatic adenoid cystic carcinoma: a retrospective study to assess initial safety and effectiveness of percutaneous CT fluoroscopy-guided permanent seed brachytherapy J Contemp Brachytherapy 34759974
2021 Oct 1 Reis-Filho, Weigelt The clinical behavior and genomic features of the so-called adenoid cystic carcinomas of the solid variant with basaloid features Mod Pathol Nature
2021 Sep 22 Mapp A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb J Am Chem Soc 34491719
2021 Sep 6 Zhu The Immune Landscape of Chinese Head and Neck Adenoid Cystic Carcinoma and Clinical Implication Frontiers Immunology 34552580
2021 Aug 27 Metcalf Centralised RECIST Assessment and Clinical Outcomes with Lenvatinib Monotherapy in Recurrent and Metastatic Adenoid Cystic Carcinoma Cancers 34503145
2021 Jul 27 Keam Randomized phase II study of axitinib versus observation in patients with recurred or metastatic adenoid cystic carcinoma Clin Cancer Res 34315722
2021 Jul 15 El-Naggar, Karpinets, Futreal, Ferrarotto, Mitani Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations Clin Cancer Res 34011559
2021 Jun 12 van Herpen PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports Eur J Nucl Med Mol Imaging 34120192
2021 Jun 10 Ha, Swiecicki, Deschler, Chau, Kaufman Management of Salivary Gland Malignancy: ASCO Guideline J Clin Oncol 33900808
2021 Jun 3 Hanna, Zon, Wirth, Park, Haddad, Lohr, Spardy Burr, Kaufman A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma Oral Oncol 34091189
2021 Jun 1 Esmaeli, El-Naggar, Ferrarotto, Bell Prognostic factors for local recurrence and survival and impact of local treatments on survival in lacrimal gland carcinoma Br J Ophthalmol 32680839
2021 Apr 1 Ha MYB RNA In Situ Hybridization Facilitates Sensitive and Specific Diagnosis of Adenoid Cystic Carcinoma Regardless of Translocation Status Am J Surg Pathol 33165092
2021 Feb 26 Sala MYB oncoproteins: emerging players and potential therapeutic targets in human cancer Oncogenesis 33637673
2021 Feb 15 Ha, Kang, Fertig, Keam Newly Identified Members of FGFR1 Splice Variants Engage in Cross-talk with AXL/AKT Axis in Salivary Adenoid Cystic Carcinoma Cancer Res 33408119
2021 Feb 1 Metcalf The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma Oral Oncol 33290961
2020 Nov 10 El-Naggar, Ferrarotto, Mitani, Futreal, Aster, Bell, Karpinets Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets Clin Cancer Res 33172898
2020 Nov 5 Ha MYB RNA In Situ Hybridization Facilitates Sensitive and Specific Diagnosis of Adenoid Cystic Carcinoma Regardless of Translocation Status Am J Surg Pathol 33165092
2020 Oct 1 Lin Adenoid Cystic Carcinoma of the Skull Base: Response to Radiation Therapy and Outcomes in a Retrospective Case Series J Neurol Surg B Skull Base 33134017
2020 Sep 28 Seiwert, Kiess Time to Debunk an Urban Myth? The “Abscopal Effect” With Radiation and Anti–PD-1 J Clin Oncol 32986527
2020 Sep 1 van Herpen 68Ga-Prostate-Specific Membrane Antigen-11-Avid Cardiac Metastases in a Patient With Adenoid Cystic Carcinoma, A Rare Presentation of a Rare Cancer Clin Nucl Med 32701807
2020 Aug 8 Schoenfeld, Wirth, Hanna A randomized phase II study of pembrolizumab with or without radiation in patients with recurrent or metastatic adenoid cystic carcinoma Int J Radiat Oncol Biol Phys 32781104
2020 Jul 17 Esmaeli, Ferrarotto, El-Naggar Prognostic factors for local recurrence and survival and impact of local treatments on survival in lacrimal gland carcinoma Br J Ophthalmol 32680839
2020 Jul 14 Aster Pharmacological disruption of the Notch transcription factor complex Proc Natl Acad Sci 32601208
2020 Apr 10 Hanna, Schoenfeld Long-term outcomes and clinicogenomic correlates in recurrent, metastatic adenoid cystic carcinoma Oral Oncol 32283496
2020 Mar 11 Baujat, Attalah A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors Eur J Cancer 32171628
2020 Feb 14 Morris, Ho, Chan, Wong The immune microenvironment and neoantigen landscape of aggressive salivary gland carcinomas differ by subtype Clin Cancer Res 32060100
2020 Jan 12 van Herpen 68Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study Theranostics 32089741
2019 Dec 21 Ness, El-Naggar, Mitani N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma Cancers 31877778
2019 Nov 1 Kaye, Kentsis MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma Oral Oncology 31606723
2016 Feb 16 Nor, Pearson Patient-derived xenograft (PDX) tumors increase growth rate with time Oncotarget 26783960
2014 Nov 1 Bakst A contouring guide for head and neck cancers with perineural invasion. Pract Radiat Oncol 25407876
2016 Feb 9 Ha, Agrawal Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res 26862087
2017 Feb 15 Nor Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clin Cancer Res 27550999
2016 Feb 1 Gonda, Ramsay Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology. Cancer Discov 26851182
2016 Feb 1 Bernstein, Knoechel, El-Naggar, Moskaluk, Aster, Faquin, Wick, Queimado An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet 26829750
2015 Feb 1 Weigelt, Reis-Filho The birth of an adenoid cystic carcinoma. Int J Surg Pathol 25185745
2014 Feb 1 El-Naggar Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diag Pathol 24238845
2014 Feb 1 Ha Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma. Otolaryngology Head Neck Surg 24493792
2014 Feb 1 Stenman Primary sinonasal adenoid cystic carcinoma presenting with skin metastases–genomic profile and expression of the MYB-NFIB fusion biomarker. Histopathology 24410806
2009 Dec 30 Ha, El-Naggar Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS One 20041111
2017 Dec 28 Weigelt, Reis-Filho MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene. J Pathol 29149504
2017 Dec 23 Ness, El-Naggar Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes. Oncotarget 29484115
2015 Dec 2 Ness Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma. Cancer Discov 26631070
2015 Dec 2 El-Naggar Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clin Cancer Res 26631609
2015 Dec 2 Klempnauer Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction. Blood 26631113
2010 Dec 15 El-Naggar Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer 20824717
2016 Dec 1 Klempnauer Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells. Mol Cancer Ther 27707899
2014 Dec 1 Kaye, El-Naggar A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Oncotarget 25587024
2014 Dec 1 Thomas, Dillon, Moskaluk Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 25487882
2012 Nov 7 Ha Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma. PLoS One 23144906
2009 Nov 3 Stenman Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. PNAS 19841262
2015 Nov 17 Mapp Targeting transcription is no longer a quixotic quest. Nat Chem Biol 26575226
2017 Nov 15 Bakst, Wong Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression. Cancer Res 28951461
2011 Nov 15 El-Naggar, Futreal Chromosomal Rearrangements and Break Points at the t(6;9) in Salivary Adenoid Cystic Carcinoma: Association with MYB-NFIB Chimeric Fusion, MYB Expression, and Clinical Outcome. Clin Cancer Res 21976542
2017 Nov 1 Aster, Faquin Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol 28914715
2012 Nov 1 Ha Molecular biology of adenoid cystic carcinoma. Head Neck 22006498
2011 Oct 21 El-Naggar Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 22020577
2018 Oct 18 Nor, Castilho UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line. Oral Oncol 30527239
2011 Oct 17 Ha Molecular biology of adenoid cystic carcinoma. Head Neck 22006498
2019 Oct 14 van Herpen Advances and challenges in precision medicine in salivary gland cancer. Cancer Treat Rev 31644971
2016 Oct 1 Ho, Morris A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma. Ann Oncol 27566443
2014 Oct 1 El-Naggar Development and characterization of salivary adenoid cystic carcinoma cell line. Oral Oncol 25086988
2014 Oct 1 Aster, Bernstein, Knoechel, Moskaluk Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov 25104330
2013 Oct 1 Stenman Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics. Ophthalmology 23725736
2011 Oct 1 El-Naggar Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 21785271
2011 Oct 1 Moskaluk Development and characterization of xenograft model systems for adenoid cystic carcinoma. Lab Invest 21709671
2010 Oct 1 El-Naggar Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res 20702610
2018 Jan 9 Knoechel Peptidomimetic blockade of MYB in acute myeloid leukemia. Nat Commun 29317678
2015 Jan 9 Ramsay Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein. Clin Transl Immunology 25671128
2020 Jan 31 Klempnauer, Stenman Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells Cancer Lett 32014461
2020 Jan 30 Baujat, Atallah Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study Eur J Cancer 32008920
2017 Jan 27 Ivanov, Yarbrough Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers. Clin Breast Cancer 28216417
2020 Jan 23 Faquin PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications Ophthalmic Plast Reconstr Surg 31990894
2017 Jan 20 Ferrarotto, Mitani, El-Naggar, Futreal, Wick Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. Clin Cancer Res 27870570
2012 Jan 1 Stenman Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. Int J Oncol 21901247